Experimental treatment being tried after setback for Margot Martini

The brave 18 month old was diagnosed with both acute lymphoblastic leukaemia and acute myeloid leukaemia last year. She recently suffered a setback when doctors found that traces of the former had returned.

Parents Yaser and Vicki, originally from Essington, said they were now 'embracing' a suggested experimental form of antibody treatment.

In a post on the Team Margot Facebook page, they said Margot would soon be 'clinically unwell'.

The post said: "At around 10am on Monday, Margot was receiving the experimental blinatumomab antibody treatment (BiTE) at Sheffield Children's Hospital.

"In herself, as of this morning she is still well, however the latest tests on Thursday revealed that the disease is around 10 per cent in her blood and 'probably 90 per cent in her bone marrow'. "Her platelets have started to fall (from experience, we know that these are the first of the blood numbers to respond) which is why Margot is pale and it wouldn't be long now before Margot is symptomatic and clinically unwell. We are embracing this suggested treatment with a sense of hope and in preference to surrendering to the disease.

"Thank you for all your well wishes, prayers, positivity and support."

Margot underwent a bone marrow transplant having been diagnosed with an extremely rare form of leukaemia last October.

Last week, the family posted a heart-wrenching video of her appealing for help, repeating Yaser's words: 'just one more' in an eight-second clip.

It mimicked a campaign being run by blood cancer charity and bone marrow register Anthony Nolan.

The Facebook group had more than 16,000 supporters.

A Swab4Margot campaign, backed by celebrities such as Stephen Fry and John Bishop, led to more than 50,000 people requesting swab kits from charity Delete Blood Cancer UK.

Eventually a match was discovered but last month Yaser and Vicki revealed their daughter had suffered a relapse.

The family's hope it was a slight set-back were dashed last week when they revealed the disease had progressed from a one per cent presence to somewhere between 60 and 80 per cent.

Last month a fundraising event inspired by her battle raised almost £600.

Well-wishers gathered at The Slade Rooms in Wolverhampton for Dance 4 Margot, an event launched to raise funds for Delete Blood Cancer.

It was initiated after two students from the University of Wolverhampton became inspired by the toddler's brave fight against leukaemia.